Challenges

The message just keeps getting clearer: The healthier your heart, the healthier your brain.
New research from Rush University Medical Center found that adhering to the American Heart Association’s Life's Simple 7 guidelines was associated with higher cardiovascular health scores and less loss of neurons in the brain. For the study, published in 2025 in JAMA Network Open, researchers followed 1,018 adults age 65 and older for almost 20 years, checking in every three years.
AHA’s heart health guidelines emphasize the importance of managing blood pressure, controlling cholesterol, reducing blood sugar, being active, eating well, losing excess weight and quitting smoking.
Data showed that those who were most faithful to the heart health guidelines had lower blood concentrations of a biomarker called neurofilament light (Nf-L), which signals damage to neurons in conditions such as Alzheimer’s disease. The link between health habits and Nf-L was particularly strong for Black adults in the study.
Earlier research cited in a 2019 report from AARP’s Global Council on Brain Health also helps to make the case. “We hope the good news from the GCBH’s review of the evidence that you can reduce your risk for dementia will really motivate people to choose healthier lifestyles,” says GCBH Executive Director Sarah Lenz Lock.
Adults 50 and older may preserve brain health by following the GCBH report's recommendations, which are similar to AHA’s recommendations and include staying physically active; maintaining a healthy weight; quitting smoking; managing diabetes; treating sleep apnea; working to control stress; and keeping blood pressure, blood sugar and cholesterol levels in healthy ranges.
Simple goals, big results
Studies have shown specific positive effects from reaching for the AHA’s seven goals. (In 2022, AHA added “Get Healthy Sleep,” making it Life’s Essential 8.) Researchers from the University of Miami and Columbia University followed more than 1,000 older adults (average age 72 at the first assessment) for six years. Participants who most closely adhered to the goals did better on tests of the brain’s processing speed, executive function and episodic memory (i.e., the ability to recall specific events, situations and experiences), according to a 2016 report in the Journal of the American Heart Association. And in another study , reported in the same journal in 2022, of 2,585 adults age 60 and over, those closely following the guidelines had better scores on tests of cognitive function.
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