Claims That Phosphatidylserine Improves Memory Lack Strong Evidence

Phosphatidylserine is a fatty chemical substance in the brain that helps keep nerve cells healthy. It’s also involved in communication between brain cells. The fat makeup in your brain changes as you age, which is why researchers have studied whether adding phosphatidylserine via supplements may prevent the cognitive decline that can come with aging.

Phosphatidylserine supplements are commonly marketed to older adults with memory complaints. But there’s not enough evidence to support the use of these supplements, says AARP’s Global Council on Brain Health. The council of scientists, health care providers, scholars and other experts reviewed research on the benefits of phosphatidylserine supplements and published its findings in a 2019 report, “The Real Deal on Brain Health Supplements.”

The GCBH wrote: “Although a few small studies found some benefit, larger studies have not confirmed that the supplement helps prevent cognitive decline or improve memory. There is not enough evidence for recommending the use of phosphatidylserine for brain health, mental functioning or prevention or treatment of Alzheimer’s disease.” 

In a 2023 review of available research into memory supplements published in the journal CNS Drugs, researchers concluded that phosphatidylserine supplements may have benefits for brain health, but, as the GCBH found, more research is needed to confirm this.